78281-72-8
- Product Name：Nepafenac
- Molecular Formula：C15H14N2O2
- Purity：99%
- Molecular Weight：254.288
Product Details;
CasNo： 78281-72-8
Molecular Formula： C15H14N2O2
Quality products make an important contribution to long-term revenue and profitability. Factory supply good quality Nepafenac 78281-72-8 with stock
1.What is the Nepafenac ?
Nepafenac is a non-steroidal anti-inflammatory drug (NSAID), usually sold as a prescription eye drop. It reduces pain and inflammation in the eyes. Nepafenac ophthalmic is used to reduce pain and swelling after cataract surgery.
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78281-61-5
2-amino-3-benzoyl-α-(methylthio)benzeneacetamide
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-
78281-72-8
nepafenac
| Conditions | Yield |
|---|---|
|
nickel;
In
tetrahydrofuran; water;
at 20 ℃;
for 0.166667h;
Product distribution / selectivity;
|
86% |
|
With
Raney nickel;
In
tetrahydrofuran;
at -5 - 5 ℃;
for 0.5h;
|
78.8% |
|
With
nickel;
In
tetrahydrofuran;
for 0.25h;
|
73% |
|
In
tetrahydrofuran;
|
6.0 g (73%) |
|
With
Raaney nickel;
In
tetrahydrofuran; water;
at 20 ℃;
for 0.25h;
|
13 g |
|
With
Raney-Ni;
|
-
-
2835-77-0
(2-aminophenyl)(phenyl)methanone
-
-
78281-72-8
nepafenac
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 2 steps
1: 1.) tert-butyl hypochlorite, 2.) triethylamine / 1.) CH2Cl2, THF, -60 deg C, 1 h, 2.) CH2Cl2, 5 min
2: 73 percent / Raney nickel / tetrahydrofuran / 0.25 h
With
tert-butylhypochlorite; nickel; triethylamine;
In
tetrahydrofuran;
|
2.What is the CAS number for Nepafenac ?
The CAS number of Nepafenac is 78281-72-8.
More information of Nepafenac 78281-72-8 are:
|
CAS Number |
78281-72-8 |
|
Density |
1.249 g/cm3 |
|
Melting Point |
177-181oC |
|
Boiling Point |
562.5 °C at 760 mmHg |
|
Flash Point |
294 °C |
|
Vapor Pressure |
1.11E-12mmHg at 25°C |
|
Refractive Index |
1.641 |
|
HS CODE |
2924299090 |
|
PSA |
86.18000 |
|
LogP |
2.80910 |
3.What are another words for Nepafenac ?
Synonyms for Nepafenac 78281-72-8:Benzoic acid,3-fluoro-2-iodo-;AHR 9434;AL 6515;Nevanac;
4.What is the molecular formula of Nepafenac?
The chemical formula of Nepafenac is C15H14N2O2 which containing 15 Carbon atoms,14 Hydrogen atoms,2 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight of Nepafenac is 254.288.
5.What is Nepafenac (78281-72-8) used for?
Nepafenac, launched by Alcon Laboratories, is a topical ophthalmic medication indicated for the treatment of ocular pain and inflammation associated with cataract surgery. Nepafenac is a prodrug of amfenac, which is an NSAID and a potent non-selective inhibitor of COX-1 (IC50=0.25 μM)) and COX-2 (IC50=0.15μM). Nepefenac itself exhibits only weak activity against COX-1 (IC50=64.3μM). Amfenac (Fenazox) has been marketed in Japan since 1986 for the treatment of rheumatoid arthritis, post-surgical pain, and inflammation. With most NSAIDs that are currently being used as topical ophthalmic agents, the maximum drug concentration is achieved on the ocular surface, with progressively lower concentrations in the cornea, aqueous humor, vitreous, and retina. Nepafenac has been found to have a penetration coefficient that is 4-28 times greater than that achieved with conventional NSAIDs such as diclofenac, bromofenac, and ketorolac. In addition, the bioconversion of nepefenac to amfenac is primarily mediated by ocular tissue hydrolases, specifically in the iris, ciliary body, retina, and choroid. The enhanced permeability of nepefenac combined with rapid bioactivation in the ocular tissue translates into superior anti-inflammatory efficacy at the target sites.
InChI:InChI=1/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)
Relevant articles related to Nepafenac:
|
Article |
Source |
|
PROCESS FOR THE PREPARATION OF NEPAFENAC |
- Page/Page column 14, (2015/01/16) |
|
Process For Preparing A Benzoylbenzeneacetamide Derivative |
- Page/Page column 5-6, (2009/12/27) |
6.Buy Nepafenac with the best price .
Mikem (Shandong) Biopharmaceutical Science and Technology Co., Ltd. is a quality supplier of Nepafenac. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Nepafenac 78281-72-8.
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